Tesamorelin & CJC-1295 (Mod GRF 1-29) & Ipamorelin peptide blend is a combination of peptides that may potentially interact with receptors in the pituitary gland. This blend may activate pituitary cells responsible for growth hormone (hGH) production.

Tesamorelin is a synthetic peptide that appears to act as an analog for growth hormone-releasing hormone (GHRH).^[1] It may potentially interact with specific receptors in the pituitary and the hypothalamus, known as GHRH receptors. The activation of these receptors appears to trigger a release of growth hormone from pituitary cells.

Mod GRF (Modified Growth Hormone-Releasing Factor), also known as CJC-1295 without DAC (Drug Affinity Complex), is a synthetic peptide analog of the endogenous growth hormone-releasing hormone (GHRH).^[2] It is a tetrasubstituted version of the shortest GHRH sequence. The peptide may potentially trigger GHRH receptors – GRF (1-29). It appears to bind to GHRH receptors in the pituitary cells associated with the release of hGH.

Ipamorelin is another synthetic peptide that may interact with pituitary cells, although it appears to do so by triggering a different receptor called the growth hormone secretagogue (GHS) receptor.^[3] These receptors, also called ghrelin receptors, are apparently found in the pituitary and the hypothalamus. By activating these receptors in an organism’s brain, Ipamorelin may potentially trigger the synthesis of HGH by pituitary cells.