Erythropoietin (EPO) is a kidney-derived glycoprotein made of 11 amino acids that has been studied for its potential to promote blood vessel growth and repair, and possible neuroprotection in the case of diabetic neuropathy. ARA-290 is a peptide derived from the beta-helix domain of EPO.[1] ARA-290 was developed with the intention of stimulating pain-mitigating and neuroprotective activity of EPO, though without promoting blood cell formation. ARA-290 has been proposed by researchers to exhibit anti-apoptotic, anti-inflammatory, and anti-permeability characteristics, akin to the endogenous glycoprotein, EPO. The peptide is being evaluated for its potential in neuropathic wound healing, immunomodulation, and within the context of Systemic Lupus Erythematosus (SLE) research.
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