Receptor Grade IGF-1 LR3 (100mcg)

Receptor Grade IGF-1 LR3 peptide is a research reagent examined in studies on cellular growth, IGF receptors, and IGF binding proteins. It contains an extended N-terminal structure of 13 amino acids and a replacement of the glutamic acid at residue 3. Additionally, the addition of arginine in the original sequence of recombinant IGF-1 (rhIGF-1), which ultimately leads to the formation of an 83 amino acid peptide. Hence, it is named IGF-1 Long R3.^[1,2] It appears to be potentially more influential on cellular activities than rhIGF-1 due to an apparent significant improvement in its biological activity. This is since it exhibits a stronger affinity for the IGF receptor and lower affinity towards other proteins that may inactivate it. Moreover, the classification of Receptor Grade refers to the purity of the material, which is considered higher than the standard Media Grade IGF-1 LR3. Media grate IGF-1 LR3 is routinely studied in cell cultures and as a research reagent, at an economical cost, for studies where biological potency is not crucial. Receptor Grade IGF-1 LR3 is considered the reagent of choice to achieve optimum results when performing any animal study and cell-based assays. Growth of mammalian cells in the presence of low concentrations of Long R3 IGF-1 appears to result in better productivity than standard concentrations of insulin and/or standard IGF-1.^[1] Researchers report that the peptide exhibited “equivalent or better performance using two recombinant CHO cell lines.” IGF-1 LR3 may be more capable of inducing the type 1 IGF receptor, potentially promoting an elevated level of intracellular signaling, cellular proliferation, and apoptosis inhibition.