SNAP-8 (200mg)

SNAP-8, or Synaptosomal-associated protein 8, is a synthetic octapeptide believed to mimic certain functionalities of its larger counterpart, SNAP-25, a protein deemed integral to neurotransmitter release and muscle contraction.^[1] Constructed from eight amino acids, SNAP-8’s structure is designed with specific modifications: an acetylated N-terminus and an amidated C-terminus, culminating in the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. It is structurally similar to another peptide known as acetyl hexapeptide-3, which also reportedly mimics a fragment of SNAP-25 and inhibits its function, leading to similar anti-wrinkle potential. By adding two amino acids to the chain of acetyl hexapeptide-3, the resultant acetyl octapeptide further enriches the field of research compounds studying cell aging and skin cell rejuvenation.^[2]

The synthesis and manufacturing of SNAP-8 comprises a final freeze-drying step called lyophilization. Generally, the crystalline powder obtained due to freeze-drying is in the form of a polymorphous compound. It may be present in aggregates and show variation in the crystal size. However, this does not appear to lead to any chemical discrepancy in its composition. Extensive experimental studies have supported the homogeneity of this compound. The usual shelf life of SNAP-8 is posited to be at least 12 months, provided the compound is stored in a clean, cool, and dry place. If the compound is intended to be stored longer than a year, the temperature should be maintained at 4 degrees Celsius. This may extend the shelf life to approximately 18 months. Refrigeration of the SNAP-8 may potentially lead to its precipitation; however, this doesn’t appear to change the integrity of the compound.