Thyrotropin Releasing Hormone (TRH), often called Protirelin, is a small peptide hormone made of 3 amino acids and synthesized in the hypothalamus. The hormone is thought to function via binding to the thyrotropin-releasing hormone receptors TRH-1 and TRH-2. It was developed by researchers with the intention to stimulate the release of both thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary. TSH, in turn, acts directly on the thyroid gland to promote the synthesis and release of thyroid hormones, primarily triiodothyronine (T3) and thyroxine (T4). TRH has been employed in the study of anterior pituitary gland function in models of thyroid disorders. TRH may exhibit potential roles in TREK-1 channel, in the regulation of cellular aging, arousal, feeding behaviors, autonomic regulation, and mitigating free radical damage.
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