Triptorelin (GnRH) (2mg)

Triptorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH), potentially mimicking the structure and function of the natural hormone. It may bind to GnRH receptors, initially stimulating the hypothalamic-pituitary-gonadal (HPG) axis, leading to a temporary surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. In turn, LH and FSH are thought to stimulate endocrine cells, like testicular cells that produce testosterone (T). However, with prolonged exposure, Triptorelin appears to desensitize the GnRH receptors, resulting in suppressed production of LH and FSH, thereby apparently reducing testosterone and estrogen levels. This potential mechanism has been extensively researched in models of androgen deprivation, exploring its potential in various contexts such as prostate cancer cells and receptor-positive breast cancer cells.